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41 out of 55 patients had a response to treatment

A response* means that the cancer reduced in size and/or completely disappeared. Responses were analyzed across 3 clinical trials in 55 adults and children with TRK fusion cancer.

75% Response Rate
22% (12 patients) had a complete response, which means that their target tumors completely disappeared
53% (29 patients) had a partial response, which means that their target tumors reduced in size by 30% or more

How long patients responded to treatment at time of analysis

  • In patients who had their tumors disappear or shrink, responses lasted between 1.6+ months and 33+ months

  • 73% of patients had a response that lasted for 6 months or more

  • 63% of patients had a response that lasted for 9 months or more

  • 39% of patients had a response that lasted for 12 months or more

  • The median§  time it took patients to respond to treatment was less than 2 months

*A response is a sum of partial response and complete response. Partial response is defined as a reduction in size of target tumors by 30% or more and complete response is defined as complete disappearance of all target tumors.

One pediatric patient with infantile fibrosarcoma (a type of cancer) that had previously not been able to be removed by surgery who had a partial response was able to have surgery and was still disease-free when the study data was analyzed.

The duration of response is how long the response to treatment lasted.

§The median is the middle number in a group of numbers.

Range: 1 month to 14.5 months.