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204 out of 339 patients had a response to treatment

A responsea means that the cancer reduced in size and/or completely disappeared. Responses were analyzed across 3 clinical trials in 339 adults and children with TRK fusion cancer.

60% Response Rate
24%b (83 patients) had a complete response, which means that their large tumors reduced in size and were able to be removed by surgery or disappeared completely
36% (121 patients) had a partial response, which means that their target tumors reduced in size by 30% or more

How long patients responded to treatment at time of analysis

  • In patients who had their tumors disappear or shrink, responses lasted for a medianc of 43.3 months, with a range of 0.0+ months and 73.7+ monthsd
  • 64% of patients had a response that lasted more than 12 months
  • 45% of patients had a response that lasted more than 24 months
  • The medianc time it took patients to respond to treatment was 2.22 monthse

a A response is a sum of partial response and complete response. Partial response is defined as a reduction in size of target tumors by 30% or more and complete response is defined as complete disappearance of all target tumors.

b 5% were patients who had a partial response and were able to have surgery to be disease free when the study data was analyzed.

c The median is the middle number in a group of numbers.

d The duration of response is how long the response to treatment lasted.

e Range: 0.89 month to 35.84 months.